Topical treatment of UC and IBD
Rectal gels and enemas based on hyaluronate or polysaccharides wash out quickly with defecation, pushing patients toward systemic steroids or TNF inhibitors with well-known systemic toxicity.
Applications / GI, Oral, Oncology
GI, Oral &
Oncology
Combining 24+ hour mucosal retention with EGFR-targeted delivery to open new options in endoscopic local therapy and chemo-related supportive care.
Clinical Pain
Today's unmet needs
Oral mucositis (OM)
OM occurs in 40–80% of patients on chemotherapy or head-and-neck radiation and disrupts eating, causes severe pain, and often interrupts therapy. Topical lidocaine rinses and barrier gels persist only for 1–2 hours.
Post-ESD / EMR ulcers
Endoscopic mucosal dissection leaves ulcers prone to bleeding and perforation. Today's practice leans on systemic PPIs because reliable local depot delivery is missing.
Post-op local therapy for gastric / esophageal cancer
Combination local chemotherapy and immunotherapy for advanced GI cancers are of interest, but no carrier reliably retains drugs at the lesion under endoscopic delivery for long enough.
Utility of NovelDDS
What NovelDDS
can do
Designed for 24+ hour mucosal retention
DOPA chemistry is rooted in the SFA measurement of Mfp-3 on mica (W ≈ 3×10⁻⁴ J/m², Lin et al. 2007) and later adhesion studies of polydopamine and PVA-DOPA films have reported mucoadhesion in the tens-of-kPa range. The Novelglue DDS platform targets 24+ hour retention against saliva, bolus and peristalsis. Novelglue-specific numbers are reported in Kawakami 2025.
EGFR-targeted delivery
A design with an EGF-fused FP2 cassette supports selective binding to EGFR-expressing epithelium and tumor tissue, exploiting the same EGF-dependent cellular responses characterized in intestinal biology (Fujii 2018 and later work).
Endoscope-compatible formats
Formulatable as gel, film or viscous liquid that delivers through endoscope channels and stays in place. Applicable to post-ESD ulcers, rectal UC, oral mucositis and more.
Excipient × drug hybrid design
Small molecules, biologics, or mRNA can be loaded or covalently fused to the FP121 core to convert existing drugs into local DDS. Designed with the FDA Novel Excipient Review Pilot Program in mind.
Future Treatments
The treatment picture that opens up
Fully-topical UC regimen
Reliably retaining 5-ASA, steroids or biologics at inflamed rectal mucosa could elevate remission rates while avoiding systemic steroid / biologic exposure.
OM prevention and healing acceleration
A 24-hour protective coating applied pre-treatment could reduce OM severity and chemotherapy interruptions, improving QoL during cancer therapy.
Post-ESD ulcer healing platform
Local PPI / growth factor / hemostatic deposition on the resection bed could reduce rebleeding and perforation, shortening admissions and shifting ESD toward ambulatory care.
Local immunotherapy carriers
Retention of immune checkpoint inhibitors, cytokines or mRNA vaccines at the tumor bed could reach strong local immunity at lower doses than systemic delivery.
引用文献 / References
- [1]
Kawakami, Y. et al. (2025) Development of the FP121 series: Hybrid proteins mimicking marine adhesive proteins with cell adhesion and proliferation activity , Materials & Design .
View on ScienceDirect →Novelglue (FP121 シリーズ) の基盤論文。細胞接着・増殖活性・スクラッチアッセイ等の一次データを含む。
- [2]
Lee, H., Dellatore, S. M., Miller, W. M., Messersmith, P. B. (2007) Mussel-inspired surface chemistry for multifunctional coatings , Science , 318 , pp. 426-430 .
DOI: 10.1126/science.1147241DOPA / polydopamine による多機能コーティングの基礎的研究。
- [3]
Lin, Q., Gourdon, D., Sun, C., Holten-Andersen, N., Anderson, T. H., Waite, J. H., Israelachvili, J. N. (2007) Adhesion mechanisms of the mussel foot proteins mfp-1 and mfp-3 , PNAS , 104 , pp. 3782-3786 .
DOI: 10.1073/pnas.0607852104Mfp-3 の mica 表面接着エネルギーを SFA で直接測定した代表論文 (W ≈ 3×10⁻⁴ J/m²)。
- [4]
Fujii, M. et al. (2018) Human intestinal organoids maintain self-renewal capacity and cellular diversity in niche-inspired culture condition , Cell Stem Cell , 23 , pp. 787-793.e6 .
DOI: 10.1016/j.stem.2018.11.016EGF を含むニッチ因子に依存したヒト腸オルガノイド維持条件を示した代表論文。