Applications / Orthopedics & Dentistry
A wet-field adhesive that does not impair bone regeneration — fractures, cartilage, meniscus, and dental GBR.
Clinical Pain
PMMA used in hip/knee arthroplasty reaches >70°C during polymerization, causing adjacent bone and soft-tissue necrosis. Residual MMA is cytotoxic and bone-cement implantation syndrome (BCIS) is reported as a perioperative risk, with clinical reviews noting markedly higher incidence in elderly / high-risk cohorts.
Screw and plate fixation depend on bone strength; in osteoporotic bone, screw cut-out and loosening are common. A reliable adjunct for voids and augmentation is missing, driving revision surgery and long bed rest.
Tears in the red-white or white zone are hard to suture; partial meniscectomy is frequent but elevates long-term OA risk. A minimally invasive way to re-approximate the margin is needed.
Autologous chondrocyte implantation (ACI / MACI) and cartilage flap repair suffer from poor graft margin sealing, driving detachment and interface delamination.
GBR membranes and socket grafts must stay in place to succeed. Fibrin glue is too weak; cyanoacrylate raises toxicity concerns.
Utility of NovelGlue
NovelGlue is designed for wet fields and holds its adhesion under blood, marrow and synovial fluid. No polymerization exotherm — osteoblast activity and bone formation are not inhibited.
Compounding with resorbable β-TCP yields a workable bone putty. AMED-backed rat femur studies show bone filling the groove by week 3 and cortical bone regrowth by week 5.
Porcine meniscus strips have been bonded in saline and fused in a 24-hour CO₂ incubator (AMED seed A). Useful as a suture substitute or augmentation for otherwise irreparable tears.
Reliable fixation for GBR membranes, socket grafts, periapical fills and similar small-void indications. Non-exothermic and low-toxicity, minimizing soft-tissue impact.
Future Treatments
Replacing or augmenting primary fixation of small fragments and intra-articular fractures with adhesion can reduce hardware footprint and speed weight-bearing / ADL recovery.
Avoiding partial meniscectomy by enabling repair could reduce long-term knee OA — relevant to sports medicine.
Fusing BMP-like motifs or antimicrobial peptides into the FP2 cassette enables derivative products for osteoporotic fractures, infection-prone defects and open fractures.
Better membrane and graft fixation narrows the outcome variance of GBR, periodontal regeneration and peri-implant bone defects.
Kawakami, Y. et al. (2025) Development of the FP121 series: Hybrid proteins mimicking marine adhesive proteins with cell adhesion and proliferation activity , Materials & Design .
View on ScienceDirect →Novelglue (FP121 シリーズ) の基盤論文。細胞接着・増殖活性・スクラッチアッセイ等の一次データを含む。
Waite, J. H. (2017) Mussel adhesion – essential footwork , Journal of Experimental Biology , 220 , pp. 517-530 .
DOI: 10.1242/jeb.134056イガイ足糸接着の分子メカニズム総説。
Lee, H., Dellatore, S. M., Miller, W. M., Messersmith, P. B. (2007) Mussel-inspired surface chemistry for multifunctional coatings , Science , 318 , pp. 426-430 .
DOI: 10.1126/science.1147241DOPA / polydopamine による多機能コーティングの基礎的研究。
Lin, Q., Gourdon, D., Sun, C., Holten-Andersen, N., Anderson, T. H., Waite, J. H., Israelachvili, J. N. (2007) Adhesion mechanisms of the mussel foot proteins mfp-1 and mfp-3 , PNAS , 104 , pp. 3782-3786 .
DOI: 10.1073/pnas.0607852104Mfp-3 の mica 表面接着エネルギーを SFA で直接測定した代表論文 (W ≈ 3×10⁻⁴ J/m²)。
