NovelGlue / Bone・Cartilage・Dental Adhesive
A wet-environment bone adhesive that does not impair bone regeneration. Usable as a bone putty with β-TCP across fixation and void-filling indications.
PMMA bone cement's exothermic polymerization (>70°C) and residual MMA cytotoxicity cause local necrosis and remodeling failure. NovelGlue has no polymerization exotherm and is based on a biocompatible protein matrix, so osteoblast activity is not suppressed. In AMED-backed rat femur defect studies, bone formation filled the groove by week 3 and cortical bone regenerated by week 5.
Compounded with resorbable β-TCP, NovelGlue forms a workable bone putty that combines β-TCP's osteoconductivity with NovelGlue's adhesion, supporting bone void filling and remodeling by newly formed bone.
Maintains 63 kPa tensile strength in blood, marrow and synovial fluid. Suits bone fragment fixation, bone graft retention and meniscus suture support — unlike mechanical fixation, bone formation advances directly at the adhesive interface.
Osteogenic motifs (BMP-like) or antimicrobial peptides can be fused into the FP2 cassette, enabling derivative products for osteoporotic fractures or infection-prone bone defects.
Benchmark against the main fixation / adhesion materials currently used in orthopedic and dental procedures. Few alternatives deliver true chemical adhesion in wet fields.
| Item | NovelGlue | PMMA bone cement | Calcium phosphate cement | Fibrin glue | Cyanoacrylate |
|---|---|---|---|---|---|
| Wet-environment adhesion | ◎ By design | × None | △ Limited | ◯ | ◯ |
| Adhesion strength | 63 kPa | Mechanical interlock | Mechanical | 240–370 Pa | High |
| Exothermic | ◎ No | × >70°C | ◎ No | ◎ No | △ Slight |
| Bone regeneration compatibility | ◎ Preserves | × Necrosis risk | ◯ Osteoconductive | △ | △ |
| Biodegradable | TBD (expected yes) | × Non-degradable | ◎ Resorbable | ◎ Degrades | △ Slow |
| Toxicity | ◎ Minimal | △ MMA | ◎ Low | ◯ Viral risk | × Formaldehyde |
References: PMMA exotherm and BCIS literature, calcium phosphate cement osteoconduction and adhesion limits (Grand View / Mordor), fibrin glue strength 0.24–0.37 N, cyanoacrylate formaldehyde-related toxicity.
Kawakami, Y. et al. (2025) Development of the FP121 series: Hybrid proteins mimicking marine adhesive proteins with cell adhesion and proliferation activity , Materials & Design .
View on ScienceDirect →Novelglue (FP121 シリーズ) の基盤論文。細胞接着・増殖活性・スクラッチアッセイ等の一次データを含む。
Waite, J. H. (2017) Mussel adhesion – essential footwork , Journal of Experimental Biology , 220 , pp. 517-530 .
DOI: 10.1242/jeb.134056イガイ足糸接着の分子メカニズム総説。
Lee, H., Dellatore, S. M., Miller, W. M., Messersmith, P. B. (2007) Mussel-inspired surface chemistry for multifunctional coatings , Science , 318 , pp. 426-430 .
DOI: 10.1126/science.1147241DOPA / polydopamine による多機能コーティングの基礎的研究。
Lin, Q., Gourdon, D., Sun, C., Holten-Andersen, N., Anderson, T. H., Waite, J. H., Israelachvili, J. N. (2007) Adhesion mechanisms of the mussel foot proteins mfp-1 and mfp-3 , PNAS , 104 , pp. 3782-3786 .
DOI: 10.1073/pnas.0607852104Mfp-3 の mica 表面接着エネルギーを SFA で直接測定した代表論文 (W ≈ 3×10⁻⁴ J/m²)。
